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Diabetes Awareness Month: How Breakthrough T1D is working to get people screened & find a cure

Friday is World Diabetes Day and November is Diabetes Awareness Month, and with 1.5 million people in the U.S. living with type 1 diabetes (T1D).

Breakthrough T1D, which is the leading global T1D research and advocacy organization, is looking to the future of diabetes research while also encouraging people to get screened.

Related: November is National Diabetes Awareness Month: What to know about Type 1 Diabetes

Type 1 diabetes is an autoimmune disease, which means your immune system has mistakenly identified the insulin-producing cells in the pancreas as a threat and attacks them. Eventually, a person produces very little insulin or none at all.

Joshua Vieth, the senior director of research at Breakthrough T1D, said that there are roughly 30 genes that have been associated for an increased risk of type 1 diabetes. However, not everyone who has those risks will go on to develop T1D because you need some sort of activating event.

Watch our interview with Vieth in the video below

Interview with Breakthrough T1D's Joshua Vieth

Through early screening and testing, Vieth said that they look for autoantibodies.

"When you have two or more autoantibodies, you're at nearly a 100% chance of developing or being diagnosed with type 1 diabetes within 10 years," he said.

T1D also develops in stages over time. There are three stages, according to Vieth.

Stage 1 is when there are multiple autoantibodies, but there are no symptoms and blood sugar is normal. Stage 2 is when there are autoantibodies present and the blood sugar is abnormal. Stage 3 is when autoantibodies are present, blood sugar is elevated and there are symptoms.

Vieth said that early screening is the "single most important thing" people can do to support therapies and move the field forward.

On top of early screening, Breakthrough is also working in a variety of other ways involving T1D, including disease-modifying therapies, which try to change the course of the disease, and working on cell replacement therapies.

Vieth said that the field has seen an incredible amount of advancement over the last three to five years.

Last year on World Diabetes Day, Breakthrough launched Project ACT, which stands for accelerate cell therapies.

"The goal of the cell therapy program is really to replace the insulin-producing cells that were lost, and to do so in a way that is sustainable and renewable," Vieth said.

It's a process where researchers are working with lab-derived islets and beta cells, according to Vieth, and then transplant those cells with the goal for people with T1D to eventually produce their own insulin again.

Breakthrough said the project brings in teams across the company, including research, regulatory, medical affairs and more, making it an organizational effort.

Thinking back to where we were a few years ago, Vieth said that researchers found at least nine or more different immune-type therapies that can preserve beta cells, meaning they can at least temporarily halt the progression of type 1 diabetes.

"We also know that in each of those studies, some people respond and some do not," he said.

He said that they're Breakthrough is working with their partners in a variety of industries major pharma, the FDA and others Β to move different therapies forward to benefit patients. He compared it to the research done involving cancer over the last decade, where clincal trials are testing different therapies together to see which gives the best response or prolongs the response.

"We're at a point now where the scientific capability has caught up. We have an approved therapy that's paved the way, and we're seeing an incredible amount of motivation amongst our academic researchers, our industry partners, our pharma partners, to move more therapies into the field," he said. "And I think it's going to be a bright few years for those living with type 1 diabetes, at risk of type 1 diabetes,or caring for somebody with type 1 diabetes.

According to Breakthrough's website, they are supporting 117 pre-clinical cell therapy research projects and five cell therapy clinical trials.

What does a cure look like for T1D? And is it possible?

"I think there is most certainly a potential for a cure," Vieth said.

However, he reminded people that there are so many factors involved in the process, from the speed of clinical trials to regulatory decisions, and so much more. Those are all things Breakthrough is working on.

"I can say that we're going to see more advancement, more breakthroughs in the next three to five years than we've seen in the last 10 to 15," Vieth said. "And that's really not wishful thinking. That's based upon what we see coming through the clinical pipeline, what the clinical trials we know that are going to report out, and the incredible research that we're funding and our partners are funding that that are continuing to drive this advancement."

Ford Racing to bring global season launch to Michigan Central Station, including reveal of Red Bull F1

Ford Racing is bringing its global launch event in 2026 to Detroit, with an event planned at Michigan Central Station during Detroit Auto Show week.

In an announcement on Tuesday, Ford said that for the first time, the annual season launch is coming to Detroit. It will take place on Jan. 15.

With the event, Ford said they'll be joined by a star-studded lineup of drivers, alongside employees, dealers, media, team owners and fans.

"From the thunderous roar of NASCAR to the grueling challenges of Mustang endurance sports car racing, and the relentless grit of our off-road teams tackling Dakar and Baja -- every facet of Fords global racing prowess will be on full display. This isnt just a launch; its a declaration of intent across every racing discipline, a true embodiment of the 'Go Like Hell' spirit that drives us," Ford said in the release.

Later that evening, Ford and Oracle Red Bull racing will team up for the season launch for Red Bull F1, where the team will reveal the liveries that will run on the car as Ford returns to F1 following a more-than two-decade absence.

The launch of the Red Bull Ford Powertrains era represents not only a bold step into the future, but a powerful expression of whats possible when world-class engineering, innovation, and passion come together. To see the energy, precision, and scale behind this project is inspiring. Its the culmination of several years of collaboration between two great names in motorsport. Were incredibly excited to begin this new chapter, driven by the same determination and excellence that defines both Ford and Red Bull," Oracle RedΒ Bull Racing CEO and Team Principal Lauren Mekies said in a statement.

"Since we announced our return to F1 with Red Bull, the Ford team have been working night and day to get ready for 2026. But this is about so much more than just the racing. It is about how we use our learnings from F1 to make our cars and trucks better for our customers. What we will learn together with Red Bull will define the technologies of the future and that is what excites me most about this relationship," Ford CEO Jim Farley said in a statement.

Saksey's, an intimate cocktail lounge with throwback vibes, opening in Detroit on Friday

A new cocktail lounge is opening in Downtown Detroit on Friday, with a throwback lounge vibe.

Saksey's, from NoHo Hospitality Group and the Gilbert family, is located at 1550 Woodward Ave. and will officially open to the public on Friday, Nov. 14. NoHo also operates San Morello, Evening Bar and Gilly's clubhouse.

According to NoHo, the new concept bar aims to channel the city's golden era in an intimate lounge. It's located in the basement of Gilly's Clubhouse.

The original Saksey's was owned by Dan Gilbert's father, Sam, and was a neighborhood tavern, NoHo Partner Luke Ostrom said.

"When we started shaping this new bar, we wanted to honor that spirit while making it entirely our own. Its not about recreating the past; its about carrying its energy forward, the sense of belonging, the humor, the craft, and letting it live in a new way," Ostrom added.

The bar was designed by Daniel Caudill of DTM Consulting, and includes dark cherry wood paneling, a brass back bar, custom mahogany tables and vintage lounge pieces from the 1960s and 1970s.

According to organizers, the cocktail menu includes Detroit inspirations, including a Root Beer Negroni, plus the bar's Teeny 'Tinis, which are small martinis.

Detroit has this special mix of grit and grace that immediately resonated with me, NoHo Bar Director Darryl Chan said in a statement. At Sakseys, were channeling that spirit through cocktails that nod to classic recipes but bend the rules. Were exploring nostalgic flavors and unique presentations throughout this menu concept, with each drink requiring serious technique, yet paired with a sense of play.

It will also offer food that includes bar favorites and desserts, all of which can be shared.

Saksey's will be open Tuesday through Thursday from 5 p.m. to 12 a.m. and Friday and Saturday from 5 p.m. to 2 a.m.

November is National Diabetes Awareness Month: What to know about Type 1 Diabetes

November is National Diabetes Awareness Month, a time to talk about the disease that affects more than 38 million people across the United States.

According to the Breakthrough T1D, more than 9.5 million people around the world live with Type 1 Diabetes.

Looking back at the progress made over the last 85 years, you can see how every learning, every policy shift, every moment spent in pursuit of a cure helped get to where we are today. It all mattered and it still does as we continue toward a future free from diabetes and all its burdens, ADA CEO Charles Henderson said in a statement.

Here's what to know about National Diabetes Awareness Month.

See the Signs of Type 1 Diabetes

According to Beyond Type 1, there are four primary warning signs of diabetes, which are commonly missed.

If you see the signs in yourself or anyone you know, you are encouraged to see a healthcare provider right away and get a simple blood sugar check.

The signs are:

Thirsty all the time

You feel dehydrated. Youre unquenchably thirsty all the time and wake up at night because you need something to drink. In kids, frequently complaining about needing something to drink. Often falsely attributed to: Hot weather or vigorous sports and exercise

The need to pee too frequently

You feel like youre peeing all the time, even getting up at night. Children past the bed-wetting phase are at it again. Or your toddler or babys diapers are constantly heavy. Often falsely attributed to: Drinking fluids to stay hydrated or a urinary tract infection.

You're just exhausted

Youre tired, your energy is low. Youre unusually fatigued and not sure why. It leads to irritability and mood swings. Often falsely attributed to: A lack of sleep, being tired from physical activity, or a viral illness. Or, just a standard lack of energy.

Losing weight and don't know why

Youre losing weight but not trying to, or losing faster than you can explain. You look thinner, your clothes are too big and your appetite changes, either significantly increased or significantly decreased. Often falsely attributed to: Appetite changes in children or teens may be attributed to growth spurts. Weight loss may be attributed to an eating disorder, increased activity or a reduced appetite.

Other common symptoms include: blurry vision, numb or tingling hands or feet, very dry skin, cuts or sores that heal very slowly, frequent urinary tract infections, frequent yeast infections.

Early screening for Type 1 Diabetes

Type one diabetes (T1D) is an autoimmune disease. Breakthrough T1D, formerly known as JDRF, reports that around 9 million people around the world live with T1D. Its a disease that can appear at any moment.

However, growing research is helping scientists and doctors learn more about the disease. One way theyre gathering that information is through early screening.

In 2023 year, Sanofi, a healthcare company that focuses on diabetes care and research, launched The 1 Pledge aimed at encouraging screening.

Dr. Jessica Dunne, the autoimmune diabetes medical director for Sanofi, said that in early screening, they test for four islet autoantibodies. Because T1D is an autoimmune disease, the immune system attacks the beta cells of the pancreas, and the beta cells are what produce insulin.

According to Dunne, they scan for four different autoantibodies. She said that research has shown that if you develop two or more of the islet autoantibodies, youre at risk for T1D.

In fact, according to Dunne, your five-year risk of developing T1D is 44%; your 10-year risk is 70%; and your lifetime risk almost reaches 100%.

Breakthrough T1D has a variety of ways that you can get screened for Type 1 Diabetes. You can learn more on the Breakthrough T1D website.

Who is at risk for Type 1 Diabetes?

Breakthrough T1D says that while the exact causes of T1D are not known, researchers have uncovered risk factors that can increase a person's likelihood of developing the disease.

However, T1D does not discriminate, and affects people of all races, ethnicities, ages and backgrounds.

Family history of T1D is one of the highest risk factors. If you have a first-degree relative (parent, sibling or child) with T1D, you're 15 times more likely to have T1D. However, nearly 85% of diagnoses happen in people who have no family members with the disease, according to Breakthrough T1D.

What is LADA?

You may have never actually heard of LADA. It stands for Latent autoimmune diabetes in adults, and is also known as Type 1.5 Diabetes.

According to The Cleveland Clinic, LADA features elements of both type 1 and type 2 diabetes, and it's often misdiagnosed as type 2.

The Cleveland Clinic also said that studies suggest between 4% and 12% of people who initially receive a type 2 diagnosis end up having LADA.

The symptoms are the same as type 1 diabetes, so people are encouraged to get screened if they show up.

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